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The risk of CRA was elevated 12 years after eradication but decreased to below baseline levels at 24 years and remained low at 46 years

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However, receptors for VIP (vasoactive intestinal peptide receptor 1 (VPAC), vasoactive intestinal peptide receptor 2 (VPAC2)) were elevated in the epithelium and glands in biopsies from smokers with chronic bronchitis [128]

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