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Recent research suggests a Metformin brain mechanism where the drug inhibits Rap1 signaling in the ventromedial hypothalamus
However, the steep costs and unequal access create substantial hurdles
It can be used as an add-on therapy to other glucose-lowering agents or as monotherapy if metformin is not tolerated or contraindicated [10, 11]
Appetite changes may begin within the first few weeks, but significant weight loss usually takes several months
Allingham PG, Brownlee GR, Harper GS, ePho M, Nilsson SK, Brown TJ
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