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Three-dimensional structure of glutathione S-transferase from Arabidopsis thaliana at 2.2 A resolution: structural characterization of herbicide-conjugating plant glutathione S-transferases and a novel active site architecture

The design integrates several key components, as outlined below: the chosen CBBBP is Tat, identified through prior animal experimentation from two candidate peptides for its superior efficacy in facilitating the transport of therapeutic agents crossing BBB

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Jia R, Hou Y, Zhang L, Li B, Zhu J

This raises a theoretical concern about hypoglycemia when combined with insulin, sulfonylureas, or other glucose-lowering agents