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Serotonin syndrome (tremor, confusion, rapid heartbeat) is extremely rare with this combination at standard doses but warrants emergency care if it occurs
For instance, a number of ongoing or completed trials are evaluating inhibitors of the PI3K-AKT-mTOR cascade, such as gedatolisib (NCT03065062) in advanced solid tumors, capivasertib (NCT04305496) in hormone receptor-positive breast cancer, and alpelisib (NCT02437318), which has shown efficacy in advanced breast cancer and is already approved for PIK3CA-mutated cases
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We have identified 2 meta-analyses assessing the combination therapy in CVOTs (Table 1)
5G, H), indicating that GGCT does not regulate ROS production through energy metabolism
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