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to 220 A.D.), Shennongs Herbal Classic recorded that BC was mainly used for convulsive epilepsy, aversion to cold first and then fever, hyperpyrexia, syncope, and spasm

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Angiopep-2, the ligand of the low-density lipoprotein receptor-related protein enhanced the BBB transcytosis of star-shaped, multibranched poly(l-glutamic acid) nanoconjugates in animals [50]