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Its progression is closely linked to the activity and stability of GPX4, making the inhibition of lipid peroxidation and the preservation of GPX4 function pivotal targets in ferroptosis-based therapeutic interventions

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In recent years, the role of GPX3 in oxidative stress has been reported, for example: GPX3 can inhibit the expression of HIF1- by regulating ROS, thereby inhibiting the growth of melanoma cells (Yi et al., 2019)

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Highlights: Motivating people to perform tasks is important, and both internal and external variables can have an impact To what extent the brain influences motivation remains a mystery to scientists According to a recent study, motivation levels may be impacted by levels of the antioxidant glutathione, which can be raised through dietary and lifestyle changes eLife , the antioxidant glutathione levels in a particular area of the brain probably have a significant influence on motivation