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Deletion of Gclc results in a drastic decrease of splenic MZB We next examined the macroscopic structure of splenic B cell follicles and the distribution of FoB and MZB in control Gclc fl/fl and mutant Gclc fl/fl Mb1-Cre + mice

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Research by Drge (2002) in Physiological Reviews demonstrated that these immune shifts may increase the likelihood of autoimmune reactivity against thyroid tissue

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