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Furthermore, researchers were unable to identify the DSIP gene, a precursor protein, or a specific receptor for the peptide
By disrupting this interaction, the peptide releases p53 to trigger apoptosis selectively in senescent cells while sparing healthy cells (Baar et al., 2017)
[7] [9] These contraindications are based on known metabolic pathways, clinical case reports, and established pharmacological principles, and are supported by clinical guidelines and expert consensus
Because testicular biopsy can damage the testes, its use is limited to highly specific cases and is often performed in conjunction with testicular sperm extraction for cryopreservation (freezing) and possible use in assisted reproductive strategies
Acknowledgements We thank Drs
