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Persistent Nausea, vomiting or diarrhea can cause fluid loss and acute kidney injury in susceptible patients

While the name has persisted it has long been recognized that the pigment staining is not due to increased melanin deposits as initially thought but instead due to lipofuscin, a cellular degradation product

The licensed product is Circadin, a 2mg modified-release tablet taken 1-2 hours before bedtime, after food, typically for an initial trial of 3 weeks with review and a maximum treatment duration of 13 weeks

52 However, it remains unclear whether radiation therapy alone is beneficial for the treatment of oral mucosal melanoma

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