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GPX4 differs from the other GPX family members in terms of its monomeric structure, a less restricted dependence on glutathione as reducing substrate, and the ability to reduce lipid-hydroperoxides inside biological membranes

doi: 10.3390/ijms24021724 93 BloomgardenZ

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On one hand, elevated ROS levels can precipitate oxidative stress, leading to macromolecular damage and subsequent activation of apoptotic pathways, such as the p53-mediated tumor suppress pathway [217]

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