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The BBB, similar to the peripheral vasculature, is susceptible to degradation and dysfunction of endothelial cells through oxidative stress, inflammation, and mechanical hemodynamic stress (i.e., high systolic pressures and pulsatility) (Moyaert et al., 2023

These features may require investigation of electrolyte levels and renal function

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This selective action may explain why they could potentially reduce drug-seeking behaviors without broadly suppressing normal motivation, although this remains to be confirmed in humans

Whatever plan you choose, you will want to make sure that it allows you to see your preferred providers and that it makes sense for your entire situation