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2013 Aug;36 Suppl 2(Suppl 2):S245-52

In Tg2576 mice, which overexpress the amyloid precursor protein (APP) with the Swedish mutations (K670N and M671L), researchers observed increased brain uptake of albumin and fluorescein, as well as increased extravasation of immunoglobulin G (IgG) and fibrin, indicating compromised BBB integrity [67,68,69]