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Headache or nausea is uncommon

In diet-induced obese mice and in NAFLD patients, activation of all three branches of the UPR is observed, with increased nuclear ATF4, ATF6, and XBP1 protein levels along with increased whole-lysate phosphorylated eIF2, phosphorylated IRE1, and FGF21 (153)

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Both peptides promote angiogenesis through complementary mechanisms, creating robust vascular networks that support comprehensive tissue regeneration