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Histone-lysine N-methyltransferase 2D (KMT2D, MLL4) is an important epigenetic regulator (Froimchuk et al., 2017)

Semaglutide 2.4 mg once weekly, a subcutaneously administered GLP-1 RA approved for obesity treatment in 2021, results in 1517% mean weight loss (WL) with evidence of cardioprotection

That potential places MOTS-c at the frontier of a profoundly important clinical question: how to maintain the metabolic benefits of exercise in bodies that can no longer perform it [2]