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both exenatide and metformin had similar effects on microvascular endothelial function measured by the reactive hyperemic index (RHI), as well as levels of inflammatory and oxidative stress markers including C-reactive protein (CRP), oxidized LDL (oxLDL), and vascular cell adhesion molecule-1 (VCAM-1) levels [63]

Tryptophan oxidation is the degradation route most commonly detected by RP-HPLC in stored melanocortin analogues, with histidine a secondary site of concern, and freeze-thaw cycling accelerates both aggregation and oxidative degradation

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The dual GLP-1/glucagon receptor agonist G49 mimics bariatric surgery effects by inducing metabolic rewiring and inter-organ crosstalk