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Liraglutide (LIRA) and semaglutide (SEMA) gained approval by the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) for weight reduction in obese individuals or people who are overweight with BMI 27 kg/m 2 and also experience at least one weight-associated comorbid situation (such as hypertension, dyslipidemia, prediabetes and OSA) combined to lifestyle modifications [71]

Other factors, such as diet and exercise, will affect weight loss success

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