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For some people, semaglutide can take things too far
PlexusDx's dual-compound GLP-Squared Injection ($289/mo) combines semaglutide with tirzepatide, activating both GLP-1 and GIP pathways
Oral GLP-1 RAs are also under development, and early data show similar weight loss efficacy to semaglutide 2.4 mg [84], which could improve convenience and potentially reduce costs through improved manufacturing and distribution efficiency
This structured approach ensures that outcomes remain measurable, consistent, and clinically meaningful
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If the patient achieves clinically meaningful weight reduction with obesity medications and if the clinician and patient feel that the medication is helping to avoid weight regain, then a weight reduction plateau should not be considered a point where medication should be discontinued, but rather the medication should be continued for weight reduction maintenance
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