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Furthermore, Gier et al

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It initiates cascades of physiological, biochemical and morphological changes that limit the productivity of plants 23

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Which means it is possible, in principle, to design molecules that produce the parts of the GLP-1 effect that you want (appetite suppression, glycemic control, cardiovascular benefit) while minimizing the parts that you do not (gastrointestinal misery, certain forms of receptor downregulation, possibly some of the off-target effects we are still characterizing)

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