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Notably, this study included broad range of GLP-1 drugs, including much older GLP-1s that have far lower anti-obesity, anti-craving, and anti-addictive effects: abiglutide (Eperzan, Tanzeum), dulaglutide (Trulicity), exenatide (Byetta, Bydureon), liraglutide (Victoza, Saxenda), lixisenatide (Adlyxin, Lyxumia), semaglutide (Ozempic, Rybelsus, Wegovy) and tirzepatide (Mounjaro) Its possible that the associations that were found would be even stronger if the study had looked exclusively at semaglutide and tirzepatide, which are the current best-in-class options for weight loss
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Clinical trial durations provide guidance as well
This issue was further aggravated by the introduction of CPPs with hydrophobic motifs, which may explain the ineffectiveness of hydrophobic CPPs for the cellular delivery of CAND
Between the overwhelming amount of noise and common misinformation, the actual science behind the drugs has gotten lost
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