268 AXL activation mediates both intrinsic and acquired resistance to targeted therapies (e.g., EGFR-TKIs in NSCLC, HER2 inhibitors in breast cancer), chemotherapy (e.g., cisplatin, gemcitabine), and antiangiogenic agents (e.g., bevacizumab)
Not enrolled or qualified for any federal, state, or government program like Medicaid, Low Income Subsidy, or Veterans Affairs (VA) Benefits
The FDA-approved prescribing information for Mounjaro (tirzepatide for diabetes) does not list anger or irritability as recognized adverse effects
The sequential approach The ATTAIN-MAINTAIN trial introduces a compelling treatment strategy: using tirzepatide and orforglipron sequentially rather than choosing one or the other
First, it reduces gastric emptying, which means food stays in the stomach longer