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1 As summarized in this review, resistance is not solely dictated by tumor-intrinsic genetic alterations but is shaped by a dynamic interplay among clonal evolution, signaling rewiring, epigenetic remodeling, altered DNA damage repair, metabolic adaptation, dysregulated cell death, TCP, microenvironmental remodeling, and hostmicrobetumor interactions

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doi: 10.1093/femsec/fiw194 56 MaM.ChristensenM

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Zinc support may be considered: During early immune stress or illness During recovery periods In seasons associated with increased immune demand Routine, long-term supplementation without assessment is generally not recommended, as excessive zinc intake may interfere with other trace minerals, including copper

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