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On the one hand, the occurrence of MOMP will lead to the release of apoptosis-related proteins into the cytoplasm, thus causing the opening of the mitochondrial permeability transition pore, which in turn results in the disruption of mitochondrial respiration, matrix swelling, and rupture of the mitochondrial outer membrane, thereby inducing apoptosis
GSH has limited permeability through the blood-brain barrier(Haddad et al., 2021), a systemic isolation which might contribute to the stability of cerebral GSH levels with pathology(Haddad et al., 2021) and aging(Gong et al., 2022
& Saltzman, E
The question is whether it delivers the intended benefits and whether it's safe
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