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[1] Adiposity and Microbiome Studies Paired with a low-fat diet, 5-amino-1-methylquinolinium was used to study whole-body adiposity and weight change in DIO mice, moving several measures toward age-matched lean controls within the study window

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10.1038/s41589-019-0408-1 22 DakengS.DuangmanoS.JiratchariyakulW.BglerO.PatmasiriwatP

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Persistent factors, including high-temperature exposure, prolonged sedentary behavior, varicocele, and cryptorchidism, can elevate local testicular temperature, disrupt the spermatogenic microenvironment, and thus impair male fertility