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Increasing attention has been directed toward the concept of a therapeutic window of opportunity, which frames early PsA as a transitional phase characterized by musculoskeletal symptoms such as arthralgia, dactylitis, and subclinical enthesitis in patients with PsO, often preceding clinically evident arthritis ( These considerations highlight the need for future studies specifically designed to evaluate GLP-1RAs in patients at high risk of PsA, particularly those with subclinical inflammation or early musculoskeletal symptoms
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GLP-1 side effects GLP-1 medications have a different side effect profile, heavily weighted toward gastrointestinal symptoms: Nausea (the most common, affecting 40-50% initially, but typically improving over weeks) Bloating and abdominal discomfort The key difference is trajectory
After starting GLP-1 drugs, some patients experienced higher rates of dizziness, fainting and other health events linked to low blood pressure
