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The enzyme glutathione reductase (GR) uses electrons derived from the pentose phosphate pathway to reduce GSSG back into two functional, active GSH molecules, restoring the cellular defense system

Comp Biochem Physiol B 86:273279 Harris RC, Tallon MJ, Dunnett M et al (2006) The absorption of orally supplied beta-alanine and its effect on muscle carnosine synthesis in human vastus lateralis

The authors show that the drastic growth arrest of the sir1 mutant is partially rescued when glutathione deficiency is introduced via the cad2 mutation, which decreases glutathione levels to 30% to 40% of wild-type levels (Cobbett et al., 1998), or pharmacologically through treatment with the GCL inhibitor buthionine sulfoximine

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Baardman, J