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Paniago-Pereira C, Maize JC, Ackerman AB
dose-response characterisation of GHS-R1a across multiple receptor-mediated outcomes simultaneously
The acidic characteristics of the TME, previously recognized as induced by the adaptive response to poor oxygenation, are attributed to hypoxia-induced anaerobic glycolysis in tumor cells, resulting in excessive lactic acid production and a subsequent pH decrease within the microenvironment
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