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J Neural Transm (Vienna) (2010) 117(8):9719.10.1007/s00702-010-0428-1 15 GoadsbyPJ
18-22 GLP-1 RAs also induce a significant reduction in body weight through delayed gastric emptying and promotion of satiety, which has led to their study in weight management
68,69 In addition to activating the cAMP/PKA pathway, activation of GLP-1R has been associated with other intracellular mechanisms such as the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) pathway, which plays a crucial role in regulating key functions like cell survival, mitochondrial activity, and autophagy, or the breakdown and recycling of damaged cellular components
We excluded patients who had a history of bariatric surgery or active and untreated primary hyperparathyroidism and patients on topiramate or orlistat
While GLP-1s make fat loss more accessible, muscle mass must be preserved intentionally
