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Given that serotonin synthesis pathways are similar between the brain and periphery and across mammalian species, we here examine in humans the following hypotheses in both CFS and hypothyroidism with fatigue: (1) serum serotonin (S-5-HT) levels are low, (2) L-carnitine supplementation is associated with increased S-5-HT levels and reduced fatigue, and (3) there exists a correlation between peripheral S-5-HT and fatigue levels

The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request

The Benefits of L-Carnitine L-Tartrate Supplementing with L-carnitine L-tartrate can benefit your health in numerous ways beyond just athletic performance