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These resistant analogues have a prolonged metabolic stability in vivo and improved biological activity, which is of great interest in the treatment of type 2 diabetes and/or obesity
In vivo half-life studies In hemizygous human FcRn Tg32 mice, groups of male mice (78 weeks, 21.530.5 g, 45 mice/cage/group) were given IV injection, into the lateral tail-vein, of 1 mg/kg of unfused WT albumin and QMP albumin variants, diluted in DPBS (pH 7.4) (Sigma-Aldrich)
Inflammation in atherosclerosis: from pathophysiology to practice
Existing therapies such as metformin and hormonal contraceptives often fail to adequately address both reproductive and metabolic complications simultaneously
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