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These data indicate that fatty-acyl GIP acts in the brain to decrease body weight via inhibition of food intake but also decreases body weight independent of GIPR in the CNS (179)

The Johns Hopkins University & Health System

Cardiometabolic Safety: Assessing cardiovascular and renal outcomes in animal models to inform human safety profiles

Each peptide targets different but complementary mechanisms, with KPV adding potent anti-inflammatory activity through NF-B inhibition