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The FDA specifically mentions their concern whether the impurities contain sequences that have an increased affinity for major histocompatibility complex (MHC), known as T-cell epitopes in their final guidance [1]
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Safety and pharmacokinetics of a human once-weekly GLP-1 analogue, semaglutide, in healthy male subjects
The most significant tirzepatide weight loss results usually occur between months 6 and 12 of treatment
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