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Weight loss was sustained throughout the study period and tirzepatide showed improvements in cardiometabolic endpoints such as fasting lipids and hypertension

Ideal candidates are near their ideal weight (within 30%), have stubborn localized fat, good skin elasticity, and seek subtle reshaping rather than dramatic changes

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The other problem is that if the waste is not cleared out, those toxic energy production by-products can cause vasoconstriction (narrowing of the arteries)