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Worldwide, many individuals are afflicted by JC, CMV, HTLV-1, and HIV-1 and develop some neurological diseases
However, the definitive Exenatide-PD3 phase 3 trial , published in The Lancet in February 2025, found no disease-modifying benefit exenatide did not slow Parkinsons progression over 96 weeks compared to placebo in 194 patients ( [25] )
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Ikizler TA, Flakoll PJ, Parker RA, Hakim RM
Phase 3 Update: TRIUMPH-4 Results Preliminary data from the ongoing Phase 3 TRIUMPH-4 trial (68 weeks) shows higher numbers than Phase 2: 12mg dose: 28.7% average weight loss (~71 lbs / 32 kg) 9mg dose: 26.4% average weight loss (~64 lbs / 29 kg) Knee osteoarthritis pain: 76% reduction (significant quality-of-life improvement) Blood pressure: Average reduction of 14 mmHg Full Phase 3 results across the TRIUMPH program (obesity, diabetes, cardiovascular outcomes, kidney outcomes) are expected throughout 2026
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