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Dual agonists that activate both GLP-1 and GIP receptors have been shown to provide more pronounced weight loss, better glycemic control, and better metabolic outcomes compared to GLP-1 RAs alone
SGLT-2 inhibitors were superior to GLP-1RA in reducing the risk of HHF and the renal outcome (24% and 22% lower risk, respectively)
However, loss of muscle mass has become a concern among patients, so understanding how to preserve lean muscle while using Mounjaro is key to achieving optimal health and sustainable long-term results
Topiramate works through several neurological mechanisms: it blocks voltage-gated sodium channels, enhances gamma-aminobutyric acid (GABA-A) activity, antagonises AMPA/kainate glutamate receptors, and weakly inhibits carbonic anhydrase
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