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Ultrasound-Guided Perineural Vitamin B12 Injection for the Peripheral Neuropathy: A Case Report The patient showed improvement of muscle power within 2 weeks

A 2025 meta-analysis of 16 studies involving 6,098 participants found no statistically significant difference between intramuscular, oral, and sublingual B12 supplementation routes

Kevin also points out that the one trial everyone is citing was funded by the company that sells the cocoa extract, which also employed the studys first author and supplied the extract itself, a depressing reality-check on who is willing to pay for nutrition research at all