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In addition, carrier-free nanoparticles GEM-CXB NPs formed by the nano self-assembly of the dual drugs gemcitabine and celecoxib, exhibit dual clearance of MDSCs and tumor cells thereby significantly enhancing antitumor effects by inducing ICD and alleviating MDSC-induced immunosuppression through MDSCs clearance (134)

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This effect may be associated with other factors, such as the inhibition of ROS production

Effect of riboflavin on the attenuation of reperfusion oxidative injury Reperfusion injury is the tissue damage that occurs when blood flows into the tissue after a period of ischaemia ( Reference Carden and Granger 49 )

Gastroenterol Clin North Am