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It can take many years (approx 20) to develop a deficiency disease in those altering their diet to one lacking in B12 due to reabsorbtion however, if failure to absorb leads to B12 deficiency disease occur within a few years (3-4)
The under eye area is a high risk zone
BSH Guidelines for the diagnosis and treatment of cobalamin and folate disorders: Treatment of established cobalamin deciency should follow the schedules in the BNF (Grade 1A)
The vast, vast majority (many quintillions of them) would be completely inert: random strings of amino acids in some incoherent order that your body simply metabolizes back into its constituent parts and repurposes into something thats actually useful
Cell and Tissue Research (2019) 4
