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DSIP recovered motor function in rats after focal stroke in a 2021 study (PMID 34500605), and a phosphorylated DSIP variant restored spatial memory and p-CREB expression in a high-altitude model (PMID 30107169)
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The peptide remains investigational without FDA approval, though its research has produced two FDA-approved drugs: afamelanotide (Scenesse) and bremelanotide (Vyleesi)
Gastrointestinal adverse events represent the most common safety concern
BPC 157 also resolves old injuries and improves joint mobility
Certain individuals may experience fatigue due to underlying health issues or lifestyle factors unrelated to semaglutide GLP-1
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