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Consistent with the potency gained from introducing the 6-carboxylic acid motif in the benzimidazole region, the cryo-EM structure showed that the carboxylic acid of PF-06883365 is making a productive interaction with an arginine residue at position 380 in the GLP-1R binding pocket
Incapsula incident ID: 420000750093414669-32490005987594955
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But in the short run, GI side effects like Nausea, vomiting, and diarrhea can leave you dehydrated, and dehydration can cause a temporary drop in kidney function that shows up as a rising creatinine and a falling eGFR
She then used her skills to synthesize large quantities of the 31 amino acid peptide and made antibodies to it
