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But the federal agency warns that these unauthorized drugs, which are illegal, pose serious health risks, adding that it still needs to evaluate them for safety, efficacy, and quality. They have not been demonstrated, through scientific trials, to provide the health benefits that they claim, according to Health Canada in an April advisory

In addition to this the excessive demands of time, money and other resources on the patient undergoing the therapy may be extreme

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(2002) Efficacy of methylcobalamin on lowering total homocysteine plasma concentrations in haemodialysis patients receiving high-dose folic acid supplementation