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Unlike earlier GLP-1 receptor agonists like semaglutide (Ozempic/Wegovy) that target a single hormone pathway, or tirzepatide (Mounjaro/Zepbound) that targets two, retatrutide activates three distinct metabolic receptors : GIP, GLP-1, and glucagon
1,2 Cutaneous reactions are the most frequent, with maculopapular exanthemas being the most common type
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this effect was plausibly exerted through the diuretic and natriuretic effect of GLP-1R agonists reducing preload
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