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Overall, the MD data was consistent with the markedly different dynamics observed in the cryo-EM 3DVA with the ECDs undergoing substantially greater dynamic motions in the Cagri-AMY 3 R complex than observed in the parallel rAmy-AMY 3 R complex (Supplementary Fig
Relaxin, on the other hand, enhances matrix metalloproteinase (MMP) activity, enzymes that degrade collagen and other extracellular matrix components, resulting in a more compliant ligament
That is a thin monotherapy evidence base for a compound this widely discussed
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