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Perhaps the best single paper on this topic comes from Oprea and colleagues and was published in the British Journal of Anaesthesia in July 2025
Int J Biol Macromol 169:122129 Patil J, Ghodke S, Jain R, Dandekar P (2018a) Extraction of vitamin D from button mushroom ( Agaricus bisporus ) using deep eutectic solvent and ultrasonication
These limitations may partially explain the discrepancy between promising preclinical results and the limited success observed in clinical trials
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They can also recommend important diet and lifestyle changes
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