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The secretagogue advantage is preserving the natural pulsatile pattern and avoiding exogenous GH's suppressive feedback, but this theoretical advantage has not translated into a demonstrated clinical superiority in head-to-head trials
Beal MF
Reported effects include modulation of matrix metalloproteinase (MMP) expression and of tissue inhibitor of metalloproteinase (TIMP) expression in fibroblast culture, an anti-inflammatory profile in skin-irritation models, and in vitro effects on keratinocyte integrin and p63 expression collectively the fibroblast stimulation and matrix-remodeling signature that defines the molecules place in the skin-research literature (Pickart et al., 2015
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