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118 Over-expression of liver SREBP-1c has been described in several IR models of including IRS2 knockout, 119 lipodystrophic and ob/ob mice
However, following overdose the half-life may be prolonged to as long as 30 hours [11, 16, 17]
This regenerative capability, combined with its oral bioavailability and blood-brain barrier penetration, positions Dihexa as a compound of significant interest for treating neurodegenerative conditions and age-related cognitive decline
40 In addition, human meningeal cells treated with a SMAD3 inhibitor were able to attenuate TGF 1-dependent MMP9 upregulation
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