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Evidence suggests that oxidative stress is already present in the early stages of AD, contributing to disease progression 96
Blots were incubated overnight at 4 C with HRP-conjugated anti-nitrotyrosine mouse mAb (1:2500 dilution in CanGetSignal solution 1,NKB-101, Toyobo, Osaka, Japan), followed by ECL-detection on a FUSION SOLO.7S.EDGE imaging system (Vilber Lourmat, Marne-la-Valle, France)
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Unlike other structurally similar compounds, it appears to exhibit a specificity that may allow for targeted experimental implications
Dark spots and uneven skin tone may also become more noticeable because of sunlight, pollution, or previous acne and irritation
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