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It means the 28-day discard rule is not driven by preservative exhaustion

Yes, but only with compounds that do not share monoamine transporter targets or stimulate central nervous system activity

Das Patent ist allerdings seit 2018 abgelaufen

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Many severely deficient patients today would have no discernible indications based on the sketchy criteria used in this survey and absolutely no comprehension of the need of the MS patient, rather that she is dependant on them