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The pharmaceutical industry has welcomed a host of therapies and vaccines into this revered club, with indications covering everything from cancer and covid-19 to arthritis and atrial fibrillation. In 1986, 10 years after it was first introduced by Smith Kline & French, sales of peptic ulcer treatment Tagamet (cimetidine) surpassed the $1 billion mark, making it the first drug in history to be classified as a blockbuster.2 Since then, the pharmaceutical industry has welcomed a host of therapies and vaccines into this revered club, with indications covering everything from cancer and covid-19 to arthritis and atrial fibrillation

10.1053/j.gastro.2017.01.003 39 GordanJ

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