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Inflammation, ectopic lipid deposition, endoplasmic reticulum stress (ERS), and oxidative stress are involved in the onset and progression of T2D and TOD by impairing insulin sensitivity and/or cell dysfunction, reciprocal with metabolic disorders
The active ingredient in medications such as Ozempic (FDA-approved for Type 2 diabetes and cardiovascular risk reduction) and Wegovy (FDA-approved for weight loss and long-term weight management), semaglutide works by mimicking the action of a natural hormone called glucagon-like peptide-1
This disrupted connectivity may contribute to cognitive deficits and depressive symptoms observed in T2DM
2.6 Protein sample preparation for mass spectrometry Protein samples (10 g/sample) were reduced with 5 mM Tris(2-carboxyethyl) phosphine and alkylated with 10 mM 2-chloroacetamide at room temperature for 20 min
