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In muscle-related changes, lean body mass (LBM) (MD = 4.61, 95%CI: -4.19 to 13.42, P = 0.31), and skeletal muscle index (SMI) (MD = 0.59, 95% CI: -0.69 to 1.86, P = 0.19) were not significantly different

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Indeed, a higher ratio of M1/M2 was observed in synovial fluid from OA knee compared with normal knees, and the ratio was significantly correlated with the KellgrenLawrence grade 49

Changes in skin tone, if any, are gradual and may take several weeks or months of consistent use to show noticeable effects

It also has the longest real-world track record of the three, with years of post-approval prescribing experience